Creating bacterial ‘fight clubs’ to discover new drugs

“Creating bacterial “fight clubs” is an effective way to find new drugs from natural sources.”

Bacteria Fight ClubThat is the conclusion of a team of Vanderbilt chemists who have been exploring ways to get bacteria to produce biologically active chemicals which they normally hold in reserve. These compounds are called secondary metabolites. They are designed to protect their bacterial host and attack its enemies, so they often have the right kind of activity to serve as the basis for effective new drugs.

… the “fight club” approach [analyzes] what happens when microbes compete.

… This procedure allowed the chemists to discover a new member of a class of biomolecules with broad-ranging activity ….

[Source]

Via Slashdot.

This could be modeled as a game, either for pure entertainment — fight, bacteria, fight! — or as an aid to research (with bacteria fights!).

Do Fruit Flies Have Emotions?

“For us, that’s a big step beyond just casually intuiting that a fly fleeing a visual threat must be ‘afraid,’ based on our anthropomorphic assumptions.It suggests that the flies’ response to the threat is richer and more complicated than a robotic-like avoidance reflex.Drosophila Thinking Question

This may be useful to game designers. Can we make a bot that actually feels fear … and if not, how close can we get?

Using fruit flies to study the basic components of emotion, a new Caltech study reports that a fly’s response to a shadowy overhead stimulus might be analogous to a negative emotional state such as fear — a finding that could one day help us understand the neural circuitry involved in human emotion.

[Source: caltech.edu]

Study:

Behavioral Responses to a Repetitive Visual Threat Stimulus Express a Persistent State of Defensive Arousal in Drosophila @ Cell Press

Media Mentions:

Fruit Flies Are Shown to Enter a Fearlike State @ NY Times

Animal emotions: Do fruit flies feel fear? @ CS Monitor

Reference:

Drosophila @ Wikipedia

See Also:

OpenWorm